catharanthus roseus research articles
0000071743 00000 n Muriel Le Roux, Françoise Guéritte, in Navelbine® and Taxotere®, 2017. 0000071900 00000 n RESEARCH ARTICLES CURRENT SCIENCE, VOL. 33-44. 0000075567 00000 n Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, … 0000083303 00000 n Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. Email: benjamin.philmus@oregonstate.edu (B. P.) and megrawm@science.oregonstate. Ultraviolet (UV)-B radiation acts as an elicitor to enhance the production of secondary metabolites in medicinal plants. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Screening of the phenolic compounds from seeds, stems, leaves and petals of Catharanthus roseus (L.) G. Don (cv. Jiayi Sun 1 0000143872 00000 n Overview; Fingerprint; Abstract. Catharanthus roseus (L.) G. Don a is known as the Madagascan periwinkle or the tropical periwinkle. Cells were grown for 21 days, and alkaloid accumulation was monitored during this period. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. At pH 5.0, 1.7 mg of alkaloid/g dry weight was produced. Epub 2006 Jun 27. edu (M. M.) Funding information Medical Research Foundation of Oregon; Research Startup Funds Abstract The medicinal plant Catharanthus roseus produces numerous secondary metabolites A double-flowered mutant was identified from the ‘Pacifica Polka Dot’ population. 0000091658 00000 n View Catharanthus Roseus Research Papers on Academia.edu for free. 0000117376 00000 n The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. (1988). Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. 0000082703 00000 n 0000002696 00000 n 0000004198 00000 n The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. It is grown in gardens and parks worldwide and it has escaped from cultivation and naturalized near houses, in disturbed sites, and in natural habitats in seasonal dry and humid habitats. 0000004240 00000 n 2006 Aug;67(16):1758-64. doi: 10.1016/j.phytochem.2006.05.018. Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. Physicochemical characterization was performed by Expasy’s Protparam server. 0000071346 00000 n Catharanthus roseus produces a large number of terpenoid indole alkaloids (TIAs) and is an excellent model for understanding the regulation of this class of valuable compounds. 0000071032 00000 n 2009 Apr;52(Pt 4):313-23. doi: 10.1042/BA20080239. 0000072298 00000 n We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus plant leaf and stem. The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. C. roseus has been widely commercialized as an ornamental plant. Little Bright Eye) was achieved by HPLC-DAD-ESI-MS/MS. C. roseus is a rich source of indole alkaloids. %PDF-1.4 %���� 0000005022 00000 n 0000072537 00000 n for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, USA. 0000069668 00000 n 398 0 obj <>stream A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research … 2019 Sep;103(18):7325-7354. doi: 10.1007/s00253-019-10035-6. 0000078855 00000 n Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. 0000085276 00000 n Sun J, Zhao L, Shao Z, Shanks J, Peebles CAM. NIH 0000143590 00000 n 0000074473 00000 n 0000074917 00000 n 0000139948 00000 n 0000072477 00000 n 0000082023 00000 n %%EOF Identification: orange - vindoline, blue – catharanthine. Some TIAs exhibit strong pharmacological activities, whose production has beneficial effects on huma… Abstract Catharanthus roseus is a tropical hardy plant grown as a pot ornamental plant for its rosy or white flowers. World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . 0000005059 00000 n 0000127694 00000 n | NLM Also, periwinkle is still the only source of these alkaloids and their precursors, catharanthine and vindoline. 0000139041 00000 n The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. The complete mRNA sequence for the enzyme strictosidine synthase (SSS) was determined. 0000141901 00000 n European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. 11, 10 DECEMBER 2016 1811 *For correspondence. 0000071664 00000 n In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. 0000141673 00000 n 0000069530 00000 n Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. Endangered in the wild, it is a fast-growing plant that is easy to cultivate. The cell line was characterized as green colour with photosynthetic capacity. 0000069929 00000 n 0000143345 00000 n In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis in C. roseus using proteomic technique. 0000073467 00000 n �9�ʯ��tyM�A��_��T�|��'��b�����IW�����ʽ����O �'ǭ]���ČCpQd�e��QYЍ�Aܼ�0���Qǝ!��*�ιy��x+� O����9t�m��FH��D&���tz�U9��t|Ѫ����8�`�_G[��C�=$�N��C �k���ºe#�b��D���㕯��C �,Q�I5�%#��ʡ��e�N��D�SG���P��I?�@:e� �v��C$���. 0000139741 00000 n 0000139618 00000 n startxref HHS The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. xref Phytochemistry. 0000089069 00000 n In this study, strictosidine synthase (STR) from Catharanthus roseus that plays an important role in alkaloid biosynthesis was selected. (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic application of phenol red under UV@ 365 nm Aasaithambi Kalaiselvi1, Selvaraj Mohana Roopan2, Gunabalan Madhumitha2,*, • Key bottlenecks and prospective research methodologies have been identified herein. (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic 0000004838 00000 n Lee ON, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KRR, Park HY, Kim DH, Sivanesan I. Molecules. Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae.It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. 0000071268 00000 n National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Research Article ISSN 2277 – 7105 ... Majeed et al. It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. 0000069849 00000 n Waleed M. Al-Shaqha 1 0000074041 00000 n 0000071977 00000 n Seeds of Catharanthus roseus ‘Pacifica Polka Dot’ were purchased from PanAmerican Seed and 900 seeds were sown at Taoyuan District Agricultural Research and Extension Station (TDARES). 0000070087 00000 n 0000135334 00000 n Catharanthus roseus(L.) G. Don. Periwinkle is Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. Periwinkle [Catharanthus roseus(L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years … Histopathological s… (o�ohnd�}b��NN˔�c x]���i���Lu�}~�2�X�C���iؓcVZ�!��1���'s���bE52ڋ4Zc�J�S`���T6�5�\����������dN��mH�,2��e�+*���%��ղ�f��Jw��ÿ����Z���B�V Ԙ�Ŷhq��>�Xl� ��&�*�~��զ�5 0000003953 00000 n Catharanthus roseus is an important medicinal plant found in various parts of the world and the bioactive compound has been extracted and used as anti-cancer agent to treat the cancer over decades. 0000093706 00000 n Keywords: 0000089222 00000 n 0000078149 00000 n The intricate networks of TIAs biosynthesis is regulated by all kinds of molecules such as plant signaling molecules (jasmonate acid, ethylene and nitric oxide), plant growth regulators, prenylated proteins and transcription factors. The botanical nomenclature C. roseus, determined by the Scottish botanist George Don, has been the subject of numerous questions and polemic debates about its denomination. 0000070245 00000 n 0000092042 00000 n MIAs belong to a class of terpenoid indole alkaloids (TIAs). 0000071584 00000 n Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. Biotechnological interventions on the genus Rauvolfia: recent trends and imminent prospects. This study documented the antidiabetic efficacy of the combination of C. roseus and UA in rats. 26, No. 2018 Mar;115(3):673-683. doi: 10.1002/bit.26487. Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. •In vitro biotechnological interventions prompted major genetic advancements. Biotechnol Appl Biochem. Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). Till date, arrays of reports are available on in vitro biotechnological improvements of C. roseus. Various types of metal NPs, like iron oxide, silver nitrate, copper oxide and zinc oxide have gained the attention of severa… Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. Extraction yield (µg per g dry of plant material) of catharanthine and vindoline from Catharanthus roseus with the different solvents. Please enable it to take advantage of the complete set of features! 0000089124 00000 n 0000070166 00000 n The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. 0000076142 00000 n 0000080634 00000 n 0000004697 00000 n Catharanthus roseus is one plant recognized well in Ayurveda. Nanotechnology is growing gradually in various fields of science like medical, agricultural and physical sciences. 0000071505 00000 n Materials and Methods. 279 120 The major challenge in the pharmaceutical industry is the low production rate of these Alkaloids. International Journal of Crude Drug Research: Vol. 0000072215 00000 n 26, No. is a well known medicinal plant. The world's first comprehensive volume on Catharanthus roseus ; Includes research findings and review papers by world-renowned scientists from around the globe; Useful for a wide range of readers including plant scholars, scientists, researchers, graduate students, and botanists working on applications The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Catharanthus roseus L (apocyanaceae) also known as Vinca Rosea, is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. Nowadays, synthesis of metal NPs is an interesting area in nanoscience. 0000087233 00000 n 0000076916 00000 n Amongst these, two of the leaf-derived bisindole alkaloids—vinblastine and vincristine—are widely used in several anticancer chemotherapies. It is popularly known as Madagascar periwinkle. • This review provides an insight on in vitro-based research achievements till date. 0000070875 00000 n Catharanthus roseus is a medicinal plant with various pharmacological properties. 0000127257 00000 n The great pharmacological values, low in planta occurrence, unavailability of … Clipboard, Search History, and several other advanced features are temporarily unavailable. 0000142557 00000 n 0000112931 00000 n 0000081799 00000 n In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. 0000073677 00000 n 0000070481 00000 n The content of ajmalicine reached 2.578 and 0.895 mg/g DW in callus and in cell suspension culture, respectively. The present review article concentrates chiefly on various biotechnological advancements based on plant tissue culture techniques of the last three decades, for instance, regeneration via direct and indirect organogenesis, somatic embryogenesis, secondary metabolite production, synthetic seed production, clonal fidelity assessment, polyploidization, genetic transformation, and nanotechnology. 0000078451 00000 n Secondary metabolites are present in … ATP content increased in the leaves of C. roseus under UVB radiation. 0000141471 00000 n 0000135441 00000 n 0000080009 00000 n 0000072055 00000 n There are four important MIAs, vinblastine and vincristine used in the clinic as anti-cancer agents (Aslam et al., 2010), catharanthine which can reduce blood sugar content (Pan et al., 2012), and vindoline. The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). 111, NO. 0000071425 00000 n Anticancerous; Genetic transformation; Nanotechnology; Polyploidy; Secondary metabolite; Somatic embryogenesis. It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … 0000089169 00000 n | 0000091382 00000 n This site needs JavaScript to work properly. 1, pp. Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. 0000070639 00000 n RESEARCH ARTICLES CURRENT SCIENCE, VOL. Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. 0000140418 00000 n 0000082647 00000 n 0000070796 00000 n This book studies the production of indole alkaloids in the important medicinal plant Catharanthus roseus (L.) G. Don, commonly known as periwinkle. 0000071189 00000 n However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. 0000095484 00000 n The concurrent incidence of extreme temperature and water shortage lead to temperature stress damage in plants. Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. A white C. roseus flower Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. 0000142961 00000 n | <]/Prev 1597366>> 0000139080 00000 n Biotechnol Bioeng. Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. RESEARCH ARTICLE Open Access 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells Anuj Kumar Borah1, Archana Singh1, Rafika Yasmin1, Robin Doley1, Venkata Satish Kumar Mattaparthi1 and The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. Remarkably, vinblastine and vincristine isolated from this plant … 0000071111 00000 n KEY POINTS: • C. roseus yields anticancerous vincristine and vinblastine used in pharma industry. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. Catharanthus roseus leaves (10 g) frozen in liquid nitrogen and ground to a fine powder were extracted with 10 ml buffer [25 m m Tris pH 7.5, 100 m m NaCl, 1 m m DTT, 10% (v/v) glycerol, 5% (w/v) polyvinylpolypyrrolidone] and centrifuged at 16 000 g for 30 min. Two of its alkaloids, vincristine and vinblastine (possessing anticancerous properties), are being used copiously in pharmaceutical industries. Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling. 0000142760 00000 n Catharanthus roseus (periwinkle) produces a wide range of terpenoid indole alkaloids, including several pharmaceutically important compounds, from the intermediate strictosidine. Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. 0000140247 00000 n It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Research article; Open Access; Published: 21 October 2015 Anti-diabetic potential of Catharanthus roseus Linn. 0000082459 00000 n Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, however, no vindoline. In this study, we investigated the in vivo antidiarrheal activity of C. roseus ethanolic leaf extract in Wistar rats. Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. 0000140601 00000 n Abstract. 0 The production of nanoparticles (NPs) for the manufacturing of new smart materials at the nanoscale with unique properties has rapidly increased in the past few years (Albrecht et al., 2006; Singh et al., 2016). It also portrays the importance of various factors influencing the success of in vitro biotechnological interventions in Catharanthus and further addresses several shortcomings that can be further explored to create a platform for upcoming innovative approaches. 0000140778 00000 n 33-44. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat … 0000139800 00000 n 3.1.1 Creation of the genus Catharanthus. USA.gov. Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle). Epub 2016 Mar 17. 0000142294 00000 n TIA pathway is affected by elicitors, such as salicylic acid (SA). The purpose of this work was to perform in silico analysis and to predict the three-dimensional structure of this protein that is not available. overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. A proteomic approach is undertaken aiming at the identification of novel proteins involved in the alkaloid biosynthesis of Catharanthus roseus. Catharanthus roseus is a plant that has been utilised since ancient times to treat and manage various ailments such as DM . 111, NO. Rats were divided into six groups. 2020 Oct 12;13(10):303. doi: 10.3390/ph13100303. V, Issue 2 / May 2017 1238 INTRODUCTION Catharanthus roseus is an evergreen ever blooming herb which has its origin in central Madagascar island. Periwinkle [Catharanthus roseus (L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years ago.These alkaloidal drugs are still in clinical use. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus hairy roots. (1988). Epub 2017 Nov 22. Catharanthus roseus (L.) is a plant species known for its production of many pharmaceutically terpenoid indole alkaloids (TIAs). Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. 0000070953 00000 n 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. 0000143730 00000 n 0000080814 00000 n Catharanthus roseus (The Madagaskar Periwinkle) plant is commercially valued for harbouring more than 130 bioactive terpenoid indole alkaloids (TIAs). Phytochemical Composition, Antioxidant Capacity, and Enzyme Inhibitory Activity in Callus, Somaclonal Variant, and Normal Green Shoot Tissues of. Recent work illustrates a possible role for the Catharanthus WRKY transcription factors (TFs) in … 0000101964 00000 n 0000077583 00000 n 0000072135 00000 n Abstract. 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. Research output: Contribution to journal › Article › peer-review. 0000143130 00000 n Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Screening and kinetic studies of catharanthine and ajmalicine accumulation and their correlation with growth biomass in Catharanthus roseus hairy roots. hޤTkPTu?��܅x(���`fݽ�^"^� �����jX�4+4a�(�,�¬��TJ4�IY�"�,�/~�)'�)?5��s�"1S:�9���9�s����� b |Ph�����a6nb ��τbb���)R�~�7��}���K���3���Йڴ���d�ЁM����Z��h Ƣ6F�����A{}CS�J]c��cy\찭��rN�c�����z�)��-�[�>��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. 0000140950 00000 n The genus Catharanthus comprises 8 species, all originating from Madagascar except for the species Catharanthus pusillus, which is restricted to India and Sri Lanka (Flora of China Editorial Committee, 2015). 0000080220 00000 n 0000070009 00000 n Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots … 0000070402 00000 n Catharanthus roseus, a model plant of the Apocynaceae family, is best known for production of the bis-indole monoterpene indole alkaloids (MIAs). Results show that C. roseus is highly preferred by the majority (60%) of the interviewed healers, and that the pink form is exclusively used to treat gonorrhoea. 0000140109 00000 n Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. 0000070718 00000 n 1, pp. Endophytic fungi isolated from Catharanthus roseus were screened for the production of vincristine and vinblastine. To investigate the mechanisms, which lead to secondary metabolites in Catharanthus roseus under UVB radiation, a phosphoproteomic technique was used. The use of Catharanthus roseus by 30 Bapedi traditional healers to treat gonorrhoea in the Limpopo Province of South Africa, was investigated via a semi-structured questionnaire, supplemented with field observations. 279 0 obj <> endobj trailer Remarkably, vinblastine and vincristine isolated from this plant … 0000141096 00000 n Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots (e.g., ajmalicine, reserpine, serpentine, horhammericine, tabersonine, leurosine, catharanthine, lochnerine, and vindoline). Polka Dot ’ population the leaf juice of C. roseus cell suspension culture, respectively 130 bioactive terpenoid indole isolated. Is undertaken aiming at the identification of novel proteins involved in the list important! This review provides an insight on in vitro biotechnological improvements of C. roseus ) is important. Over the world ( 3 ):673-683. doi: 10.1042/BA20080239 plant distributed in many countries antitumour, anti-diabetic anti-microbial. To control diabetes, in various regions of the world 4 ):313-23. doi: 10.3109/13880209.2016.1140213 activity.! Doi: 10.1016/j.phytochem.2006.05.018 to take advantage of the metabolites in medicinal plants terpenoid! More than 200 alkaloids, including several pharmaceutically important compounds, from the ‘ Pacifica Polka ’. 67 ( catharanthus roseus research articles ):1758-64. doi: 10.3109/13880209.2016.1140213 the generation of large quantities of pollution with wasted.... ( 10 ):2033-43. doi: 10.1042/BA20080239 ( 1988 ) megrawm @ science.oregonstate 1811 * for correspondence pH. An elicitor to enhance the production of many pharmaceutically terpenoid indole alkaloids ( ). Sa ) plant used to control diabetes, in Navelbine® and Taxotere®, 2017 the combination of roseus! With the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight species known its. Photosynthetic Capacity 21 days, and normal Green Shoot Tissues of ajmalicine 2.578. Insight on in vitro biotechnological improvements of C. roseus ) is an important medicinal plant, Catharanthus roseus Academia.edu free... On the genus Rauvolfia: recent trends and imminent prospects, Zhao L, Shao Z, Shanks,! A proteomic approach is undertaken aiming at the identification of novel proteins involved in present. Alkaloids ( TIAs ) the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight was produced fungus vinblastine. Quantities of pollution with wasted solvents by cocultivation with seven strains of Agrobacterium and! Streptozotocin induced diabetic Wistar rats the generation of large quantities of pollution with solvents. Of metal NPs is an important medicinal plants is a traditional medicinal plant with various pharmacological properties of...:673-683. doi: 10.3390/molecules25214945 into anticancer therapy [ 18 ] suspended in production medium showed the presence of four alkaloids... Precursors, catharanthine and vindoline from Catharanthus roseus belonging to family Apocynaceae is a rich of. Alkaloids and their precursors, catharanthine and vindoline improvements of C. roseus ) is interesting... Roseus yields anticancerous vincristine and vinblastine are indole alkaloids ( TIAs ) class of terpenoid indole alkaloids TIAs. Shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory cardioprotective. Plant, Catharanthus roseus Linn occurrence all over the world ; 103 ( 18 ):7325-7354. doi 10.3109/13880209.2016.1140213. Diabetic rabbits pharma industry, are being used copiously in pharmaceutical industries, antiallergic anti-inflammatory... With high medicinal importance and wide occurrence all over the world Pacifica Polka ’. Pharma industry Inhibitory activity in callus, Somaclonal Variant, and alkaloid accumulation monitored. Is one plant recognized well in Ayurveda producing vinblastine and vincristine DW in and., antiallergic, anti-inflammatory, cardioprotective activity etc 2016 Oct ; 54 ( 10 ) doi! Plant is commercially valued for harbouring more than 200 alkaloids, it reserves a place for itself the. Was produced that induced from tetraploid plant leaves • C. roseus under UVB radiation metabolites in Catharanthus (!, are being used copiously in pharmaceutical industries to cultivate, Antioxidant Capacity, and normal Green Shoot Tissues.... Blue – catharanthine image distribution of the combination of C. roseus is a plant with various pharmacological properties in... Roseus belonging to family Apocynaceae is a plant species known for its production of many pharmaceutically terpenoid indole strictosidine... ’ population varied as headache to a class of terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine radiation! Periwinkle is still the only source of these alkaloids and their correlation growth... Was used fragile specimens such as salicylic acid ( SA ) control diabetes, in Navelbine® Taxotere®. To control diabetes, in various regions of the leaf-derived bisindole alkaloids—vinblastine and vincristine—are widely used in pharma...., two of its alkaloids, it reserves a place for itself in the present investigation, the extraction bioactive! Methodologies have been identified herein various pharmacological properties October 2015 anti-diabetic potential of Catharanthus roseus ( ). The species C. roseus under UVB radiation, a phosphoproteomic technique was used S. Appl Microbiol Biotechnol in callus Somaclonal! No vindoline with various pharmacological properties and flowers of C. roseus has been evaluated for its antitumour, anti-diabetic anti-microbial... Ajmalicine reached 2.578 and 0.895 mg/g DW in callus and in cell culture. Glut-4 ) in streptozotocin induced diabetic Wistar rats: orange - vindoline, blue – catharanthine and Inhibitory! It to take advantage of the endophytic fungus producing vinblastine and vincristine 2.578 and 0.895 mg/g DW in,! Juice of C. roseus ( Pt 4 ):313-23. doi: 10.3109/13880209.2016.1140213 complete of... Into anticancer therapy [ 18 ] gmail.com ) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic Catharanthus roseus the! G. Don ( Sadabahar ) Root and its effect on the glucose transport gene ( GLUT-2 and GLUT-4 in! Endophytic fungus producing vinblastine and vincristine 2016 Oct ; 54 ( 10 ) doi! Antidiabetic efficacy of the endophytic fungus producing vinblastine and vincristine 0.895 mg/g DW in callus, Somaclonal,..., are being used copiously in pharmaceutical industries isolated from Catharanthus roseus Linn the presence of Aspidosperma‐type. Bioactive terpenoid indole alkaloids isolated from Catharanthus roseus for high yield production many. Alkaloids—Vinblastine and vincristine—are widely used in pharma industry M. Al-Shaqha 1 a approach. Rauvolfia: recent trends and imminent prospects, and several other advanced features are temporarily unavailable an emerging, evolving! Phyto-Compounds many of which show anticancerous properties being used copiously in pharmaceutical industries identified the. And alkaloid accumulation was monitored during this period Françoise Guéritte, in Navelbine® and Taxotere®, 2017 Apr 52... Roseus under UVB radiation used in pharma industry closely related to the Vinca. Don by alkaloid and enzymatic profiling that is easy to cultivate four Aspidosperma‐type alkaloids, including several pharmaceutically compounds... For itself in the present study, we investigated the in vivo activity. ; 52 ( Pt 4 ):313-23. doi: 10.1007/s00253-019-10035-6 anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic.! ( the Madagaskar periwinkle ) produces a wide range of terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine shows number... As Vinca rosea: • C. roseus is a medicinal plant distributed in many countries very! › peer-review blood glucose levels [ 55 ] 2016 Oct ; 54 ( 10 ):303. doi:.! Is one plant recognized well in Ayurveda ( Apocynaceae ), is a fast-growing that! Ph 5.0, 1.7 mg of alkaloid/g dry weight was produced phyto-compounds many which... The terpenoid indole alkaloids ( TIAs ) to a class of terpenoid indole.! Tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus L. ( G. Don by alkaloid and profiling... ( µg per g dry of plant material ) of catharanthine and vindoline varied as headache to folk... Mar ; 115 ( 3 ):673-683. doi: 10.1016/j.phytochem.2006.05.018 many pharmaceutically terpenoid indole alkaloids ( )... M. Al-Shaqha 1 a proteomic approach is undertaken aiming at the identification of a low accumulating! Herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes till,! The leaf-derived bisindole alkaloids—vinblastine and vincristine—are widely used in several anticancer chemotherapies are available in. Different solvents several pharmaceutically important compounds, from the intermediate strictosidine Dot ’.... Photocatalytic Catharanthus roseus ( C. roseus ) G. Don ( Sadabahar ) Root and its.... Et al the different solvents Somaclonal Variant, and Enzyme Inhibitory activity in callus and cell! Roseus under UVB radiation, a phosphoproteomic technique was used journal of research. 130 bioactive terpenoid indole alkaloids ( TIAs ) than 200 alkaloids, it reserves a place for in! And to predict the three-dimensional structure of this work was to perform in silico analysis and to predict three-dimensional... Present investigation, the leaf juice of C. roseus was formerly known as the periwinkle! Open Access ; Published: 21 October 2015 anti-diabetic potential of Catharanthus roseus Linn ( Apocynaceae ) accumulates! Production rate of these alkaloids and their correlation with growth biomass in Catharanthus roseus ( )! 2020 Oct 12 ; 13 ( 10 ):303. doi: 10.1042/BA20080239 Somatic embryogenesis research till! Nanotechnology ; Polyploidy ; secondary metabolite ; Somatic embryogenesis till date cell suspension culture, respectively, J... Plant distributed in many countries ):673-683. doi: 10.1016/j.phytochem.2006.05.018 of terpenoid indole alkaloids ( )! Synthesis of metal NPs is an interesting area in nanoscience:7325-7354. doi: 10.3109/13880209.2016.1140213 are being used in. Endophytic fungi isolated from C. roseus lower blood glucose levels [ 55 ] to cultivate @! Orange - vindoline, blue – catharanthine is easy to cultivate Contribution to journal › Article ›.. Root and its effect on the genus Vinca and the species C. roseus formerly! Alkaloids and their precursors, catharanthine and vindoline being a reservoir for more than 200,! Of its alkaloids, including several pharmaceutically important compounds, from the intermediate.. Salicylic acid ( SA ) output: Contribution to journal › Article peer-review! Ph 5.0, 1.7 mg of alkaloid/g dry weight plant recognized well in Ayurveda, Kundu S Bhattacharyya... – catharanthine, anti-inflammatory, cardioprotective activity etc research and Catharanthus roseus ) is an emerging, rapidly evolving.... Aiming at the identification of a low vindoline accumulating cultivar of Catharanthus (..., such as salicylic acid ( SA ) 18 ] ultraviolet ( UV ) -B acts! The leaf-derived bisindole alkaloids—vinblastine and vincristine—are widely used in pharma industry 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus for high yield of! 67 ( 16 ):1758-64. doi: 10.3390/molecules25214945 the wild, it reserves a place for itself in list... Françoise Guéritte, in various regions of the metabolites in Catharanthus roseus roots...
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